Studies on the Role of Fibrinogen on Lipid Deposition into the Aorta.

The purpose of this report was to determine whether the presence of fibrinogen has an effect on the deposition of ƒÀ-lipoprotein into the aorta. Chromatography with citrated ethanol saline system displayed lipids at the origin, only when chromatograms of samples of acid polysaccharides plus plasma were run on filter papers. They were absent from preparations of acid polysaccharides and serum. The results obtained with the fluorescentantibody technique indicated that accumulations of ƒÀ-lipoprotein in the intima were associated with the presence of fibrin. It is suggested that fibrinogen enhances the deposition of lipid complexes from abnormally lipaemic sera.